The COVID-19 pandemic is an unprecedented global health crisis that has affected all countries and territories in the world, causing more than three million deaths. In response to the COVID-19 pandemic toll in Africa, several countries mobilized significant financial, human, logistical and technical support to strengthen pre-existing public health response capacities of their health systems. Several countries instituted non-pharmaceutical interventions with varying intensities and coverage such as closure of education and religious institutions, banning of public transport and overnight curfew. These interventions have the potential to significantly disrupt national and household economies and could negatively impact health service delivery and uptake. These effects could vary across countries depending on the nature and extent of the non-pharmaceutical interventions as well as the fidelity with which they are implemented. This project aimed to assess and curate the (i) response to the COVID-19 pandemic in Africa and the outcomes in terms of COVID-19 control and (ii) continuity of essential non-COVID-19 health services within the COVID-19 period, to inform the COVID-19 response and recovery as well as health system resilience to future disease outbreaks in Africa. The study is conducted in four countries: The Democratic Republic of Congo (DRC), Nigeria, Senegal, and Uganda.