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School of Public Health
College of Health Sciences, Makerere University

Trial Site Manager (Medical)

Date of Validity

Vacancy Details

Makerere University School of Public Health in collaboration with Vector Control Division - Ministry of Health Uganda (VCD) and the University of Cambridge is running a two-year clinical trial; Impact of increased praziquantel frequency on childhood fibrosis in persistent morbidity hotspots (FibroScHot). FibroScHot is funded by the European and Developing Countries Clinical Trial Partnership (EDCTP) and is co-sponsored by Cambridge University Hospital Trust, University of Cambridge and VCD.

 The Trial aims to determine whether increasing the frequency of praziquantel treatment to 2 or 4 times a year reduces the prevalence of periportal liver fibrosis observed by ultrasound within school children in Hoima District.  Exploratory outcomes will include investigations into the host immune response and the parasite genetics, to determine causes of the persistent morbidity observed. The wider consortium brought together to fulfil the implementation of the trial includes 10 research groups based across 3 countries.  The trial aims to enrol 600 school children, aged between 6 and 14 years of age.

The project seeks to recruit a Trial Site Manager (Medical) to support the implementation of its activities in Hoima. The Trial Site Manager will work under the overall supervision of the Principal Investigator and will be based in Hoima with frequent travel to Kampala. 

Job Title: Trial Site Manager (Medical)

No. of vacancies: 01 (one)


Working together with the Principal Investigator, the Trial Site Manager will be responsible for the field implementation of the Trial including;

  • Play a key role in the clinical aspects of the trial, providing a qualified medical contact for the parents/guardians of the participants, should any adverse events occur or queries related to the trial arise
  • Maintain an up-to-date record of all enrolments and withdrawals from the trial
  • Train any community field workers in the trial protocol and GCP
  • Maintain the adverse events/effects trial log, and to aid access to standard of care treatment those who for require it
  • Track progress against targets and documenting the project progress
  • Report any severe adverse events/effects to the VCD and University of Cambridge Investigators, for onward reporting to sponsors and ethical review committees 
  • Attend the trial treatment and 24-hour follow-up days, to ensure that all adverse effects of treatment suffered by the participants are recorded according to GCP Guidelines
  • Compile the mid-term and end of trial data safety reports for assessment by the independent clinically qualified members of the Trial Steering Committee, who will also act as the Drug Safety Management Board for the FibroScHot Trial.
  • Ensure that the FibroScHot trial is run to international standards, complying with the International Council on Harmonisation Good Clinical Practice (GCP) Guidelines


Essential Qualifications and Skills

  • Bachelor of Medicine and Bachelor of Surgery  (MBChB)
  • Registration with Medical Council in Uganda
  • Knowledge of Good Clinical Practice Guidelines, or willing to undertake training
  • Ability to converse in Alur and or Runyoro
  • Good IT skills      
  • Ability to work in a multidisciplinary group

Duration and Remuneration           

The post is for three years. Remuneration is competitive and will be paid pro rata.  All associated field costs will be covered.

How to apply

Interested candidates are invited to submit their application, CV with contact details of three referees to:

The Dean,
Makerere University School of Public Health,
P.O. Box 7072, Kampala, Uganda.
Candidates may submit electronic versions of the application to     

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